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The model for 90Sr internal irradiation processes of murine rodents for use in dosimetry
V. V. Pavlovskyi*, M. V. Strilchuk
Institute for Nuclear Research, National Academy of Sciences of Ukraine, Kyiv, Ukraine
*Corresponding author. E-mail address:
vladvpav@gmail.com
Abstract: A computer model of a murine rodent has been developed for use in dosimetric calculations. The model is based on information from scientific sources regarding anatomical features of animals' body and skeleton, as well as the structure and chemical composition of bones and bone marrow. The Geant4 software library, designed for the simulation of nuclear physics processes, was used in creating the model. The developed model enables realistic simulation of 90Sr internal irradiation processes of murine rodent bone marrow, corresponding to the exposure of animals under natural conditions of the Chornobyl Exclusion Zone ecosystems.
Keywords: computer modeling, murine rodents, dosimetry.
References:1. P.W. Durbin et al. Gross composition and plasma and extracellular water volumes of tissues of a reference mouse. Health Phys. 63 (1992) 427. https://doi.org/10.1097/00004032-199210000-00007
2. W. Segars et al. Development of a 4-D digital mouse phantom for molecular imaging research. Mol. Imaging Biol. 6 (2004) 149. https://doi.org/10.1016/j.mibio.2004.03.002
3. C. Hindorf, M. Ljungberg, S.-E. Strand. Evaluation of parameters influencing S values in mouse dosimetry. J. Nucl. Med. 45 (2004) 1960. https://jnm.snmjournals.org/content/45/11/1960
4. M.S. Muthuswamy, P.L. Roberson, D.J. Buchsbaum. A mouse bone marrow dosimetry model. J. Nucl. Med. 39 (1998) 1243. https://jnm.snmjournals.org/content/39/7/1243.long
5. T.E. Hui et al. A mouse model for calculating cross-organ beta doses from yttrium-90-labeled immunoconjugates. Cancer 73 (1994) 951. https://doi.org/10.1002/1097-0142(19940201)73:3+%3C951::AID-CNCR2820731330%3E3.0.CO;2-1
6. W.H. Miller et al. Evaluation of beta-absorbed fractions in a mouse model for 90Y, 188Re, 166Ho, 149Pm, 64Cu, and 177Lu radionuclides. Cancer Biother. Radiopharm. 20 (2005) 436. https://doi.org/10.1089/cbr.2005.20.436
7. M.A. Keenan et al. RADAR realistic animal model series for dose assessment. J. Nucl. Med. 51 (2010) 471. https://doi.org/10.2967/jnumed.109.070532
8. R.J. Di Masso, G.C. Celoria, M.T. Font. Morphometric skeletal traits, femoral measurements, and bone mineral deposition in mice with agonistic selection for body conformation. Bone 22 (1998) 539. https://doi.org/10.1016/S8756-3282(98)00029-5
9. B.R. Gulner, Z.S. Navabi, S.B. Kodandaramaiah. 3D morphometric analysis of mouse skulls using microcomputed tomography and computer vision. bioRxiv (2022). https://doi.org/10.1101/2022.10.26.513830
10. C. Nombela-Arrieta, M.G. Manz. Quantification and three-dimensional microanatomical organization of the bone marrow. Blood Adv. 1 (2017) 407. https://doi.org/10.1182/bloodadvances.2016003194
11. V.L. Shaposhnikov. Distribution of bone marrow cells in the mouse skeleton. Bull. Exp. Biol. Med. 87 (1979) 510. https://doi.org/10.1007/BF00806699
12. A.C.B. Hooper. Skeletal dimensions in senescent laboratory mice. Gerontology 29 (1983) 221. https://doi.org/10.1159/000213120
13. H. Shimizu et al. Principal component analysis for the size of skeletal bones in mice. Jpn. J. Zootech. Sci. 56 (1985) 495. https://doi.org/10.2508/chikusan.56.495
14. I. Bab et al. Micro-Tomographic Atlas of the Mouse Skeleton (New York: Springer, 2007) 205 p. https://doi.org/10.1007/978-0-387-39258-5
15. F. Muñoz-Muñoz, D. Perpiñán. Measurement error in morphometric studies: Comparison between manual and computerized methods. Ann. Zool. Fenn. 47 (2010) 46. https://doi.org/10.5735/086.047.0105
16. A. Micheau, D. Hoa. Labeled cross-sectional anatomy of the mouse on micro-CT. IMAIOS, 2023. https://doi.org/10.37019/vet-anatomy/564757
17. V.I. Luzin et al. Chemical composition of different sections of long tubular bones following implantation of biogenic hydroxyapatite. Trauma 10 (2009). (Rus) https://www.mif-ua.com/archive/article/20214
18. I. Benko et al. Major and trace elements in mouse bone measured by surface and bulk sensitive methods. Nucl. Instrum. Methods B 279 (2012) 223. https://doi.org/10.1016/j.nimb.2011.10.059
19. A.A. Dietz. Composition of normal bone marrow in rabbits. J. Biol. Chem. 165 (1946) 505. https://doi.org/10.1016/S0021-9258(17)41163-X
20. Ż. Steiner-Bogdaszewska et al. The mineral composition of bone marrow, plasma, bones and the first antlers of farmed fallow deer. Animals 12 (2022) 2764. https://doi.org/10.3390/ani12202764
21. M. Girotra et al. Mineral and amino acid profiling of different hematopoietic populations from the mouse bone marrow. Int. J. Mol. Sci. 21 (2020) 6444. https://doi.org/10.3390/ijms21176444
22. S. Agostinelli et al. Geant4 - a simulation toolkit. Nucl. Instrum. Methods A 506 (2003) 250. https://doi.org/10.1016/S0168-9002(03)01368-8
23. Autodesk 3ds Max. https://www.autodesk.com/products/3ds-max/overview
24. C.M. Poole et al. A CAD interface for GEANT4. Australas. Phys. Eng. Sci. Med. 35 (2012) 329. https://doi.org/10.1007/s13246-012-0159-8
25. Live Chart of Nuclides. IAEA Nuclear Data Services. https://www-nds.iaea.org/relnsd/vcharthtml/VChartHTML.html
26. Yu.A. Maklyuk et al. Assessment of 90Sr and 137Cs distribution pattern in organs and tissues of bank vole (Clethrionomys glareolus) under conditions of the Chornobyl zone. Nucl. Phys. At. Energy 2 (2006) 115. (Rus) https://doi.org/10.15407/jnpae2006.02.115