Ядерна фізика та енергетика Nuclear Physics and Atomic Energy   ISSN: 1818-331X (Print), 2074-0565 (Online)   Publisher: Institute for Nuclear Research of the National Academy of Sciences of Ukraine   Languages: Ukrainian, English   Periodicity: 4 times per year   Open access peer reviewed journal

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І. М. Karnaukhov¹, V. І. Slisenko², B. V. Borts¹, А. Yu. Zelinsky¹, L. М. Sidenko^1,*, І. V. Ushakov¹, О. V. Nevara¹, І. V. Patozkin¹, А. О. Mytsykov¹, О. V. Bykhun¹, V. V. Tryshyn², І. А. Maliuk², V. М. Makarovskyi<sup>2

1</sup> National Science Center "Kharkiv Institute of Physics and Technology", Kharkiv, Ukraine
² Institute for Nuclear Research, National Academy of Sciences of Ukraine, Кyiv, Ukraine

^*Corresponding author. E-mail address: farmalori77@gmail.com

Abstract: This paper presents the results of the first testing of technological equipment to produce radiopharmaceuticals "Sodium pertechnetate (^99mTc), extraction, solution for injection" with technological equipment located in the laboratory of radioisotope production at NSC "Kharkiv Institute of Physics and Technology" (KIPT). The "hot" cells and technological equipment mounted inside the cells meet the requirements of the European standard and guarantee the safety of operators during the production process. The technology for producing radiopharmaceuticals is based on the extraction of ^99mTc with methyl ethyl ketone from alkaline solutions of ⁹⁹Mo. ^99mTc is obtained as a daughter product of ⁹⁹Mo radioactive decay, which is formed as a result of the ⁹⁸Mo(n, γ)⁹⁹Mo radiation capture reaction during irradiation of natural molybdenum oxide powder MoO₃ (⁹⁸Mo 24.13 %) with neutrons inside the core of a nuclear facility. Since the NSC KIPT Subcritical Assembly "Neutron Source" is at the stage of physical start-up, the ampoules with MoO₃ powder were irradiated in the core of the WWR-M research nuclear reactor of the Institute for Nuclear Research of the National Academy of Sciences of Ukraine. The results of gamma spectrometric studies of the initial solution containing radioisotopes ⁹⁹Mo + ^99mTc and the finished solution with radioisotope ^99mTc showed the absence of radionuclide impurities.

Keywords: radiopharmaceutical, radioisotope, ^99mTc, solvent extraction, radionuclidic purity.

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