Nuclear Physics and Atomic Energy

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Nuclear Physics and Atomic Energy

  ISSN: 1818-331X (Print), 2074-0565 (Online)
  Publisher: Institute for Nuclear Research of the National Academy of Sciences of Ukraine
  Languages: Ukrainian, English
  Periodicity: 4 times per year

  Open access peer reviewed journal


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Nucl. Phys. At. Energy 2024, volume 25, issue 4, pages 379-387.
Section: Radiobiology and Radioecology.
Received: 10.07.2024; Accepted: 28.08.2024; Published online: 26.12.2024.
PDF Full text (ua)
https://doi.org/10.15407/jnpae2024.04.379

Pathological and compensatory reactions in the blood system of small rodents exposed to chronic low dose ionizing radiation

A. I. Lypska, N. K Rodionova, N. M. Riabchenko*, O. O. Burdo, V. A. Shytiuk

Institute for Nuclear Research, Kyiv, Ukraine

*Corresponding author. E-mail address: nryabchenko@ukr.net

Abstract: Changes in the blood systems of small rodents inhabiting for many generations the Chornobyl Exclusion Zone territories with a relatively low level of radionuclide pollution were studied. Animals’ calculated absorbed doses were in the low dose and dose rate ranges. Dual changes in the blood system were registered, damaging as well as reactive, and high variability of hematological and cytogenetic indicators was observed. Identified changes may be caused by the cumulative effects of chronic radiation exposure.

Keywords: radionuclides, chronic exposure, low doses, bank vole, Chornobyl Exclusion Zone, hematopoietic system, cytogenetic abnormalities.

References:

1. C. Mothersill, C. Seymour. Low dose radiation mechanisms: The certainty of uncertainty. Mutat. Res. Genet. Toxicol. Environ. Mutagenesis 876-877 (2022) 503451. https://doi.org/10.1016/j.mrgentox.2022.503451

2. C. Mothersill et al. Factors influencing effects of low-dose radiation exposure. Health Physics 126 (2024) 296. https://doi.org/10.1097/HP.0000000000001816

3. V.M. Voitsitskiy et al. Ðarticipation of the adaptive potential of biological systems in forming their reliability. Ekolohichni Nauky 1(52) Vol. 2 (2024) 119. (Ukr) https://doi.org/10.32846/2306-9716/2024.eco.1-52.2.22

4. T.G. Glazko, D.M. Grodzinsky, V.I. Glazko. Polyfactoriality of adaptation to chronic low-dose radiation in small rodents. Reports of the National Academy of Sciences of Ukraine 3 (2005) 179. (Rus)

5. S.P. Gashchak et al. Species structure peculiarities of insectivores and rodents of the Chornobyl Exclusion Zone. Vestnik Zoologii 34 (2000) 51. (Rus) http://dspace.nbuv.gov.ua/bitstream/handle/123456789/64611/05-Gashchak.pdf?sequence=1

6. B. Oskolkov et al. Radiation dose assessment for the biota of terrestrial ecosystems in the shoreline zone of the Chernobyl nuclear power plant cooling pond. Health Phys. 101(4) (2011) 349. https://doi.org/10.1097/HP.0b013e3182242e02

7. À. Lypska et al. Radiation-induced effects on bone marrow of bank voles inhabiting the Chornobyl exclusion zone. International Journal of Radiation Biology 98(8) (2022) 1366. https://doi.org/10.1080/09553002.2022.2047823

8. M.V. Zheltonozhska et al. New methodological approaches to the simultaneous measurement of the 90Sr and 137Cs activity in environmental samples. Nucl. Phys. At. Energy 13(4) (2012) 403. (Rus) https://jnpae.kinr.kyiv.ua/13.4/Articles_PDF/jnpae-2012-13-0403-Zheltonozhska.pdf

9. J.E. Brown et al. A new version of the ERICA tool to facilitate impact assessments of radioactivity on wild plants and animals. J. Environ. Radioactivity 153 (2016) 141. https://doi.org/10.1016/j.jenvrad.2015.12.011

10. O.S. Monastyrska. Clinical Laboratory Tests. M.B. Shehedin (ed.) (Vinnytsia: Nova Knyha, 2007) 165 p. (Ukr)

11. M.L. Turgeon. Clinical Hematology: Theory and Procedures (Lippincott Williams & Wilkins, 2011) 632 p. Google books

12. H. Tvedten, R.E. Raskin. Chapter 4. Leukocyte Disorders. In: M.D. Willard, H. Tvedten (Eds.). Small Animal Clinical Diagnosis by Laboratory Methods. 5th ed. (W.B. Saunders, 2012) p. 63. https://doi.org/10.1016/C2009-0-59996-5

13. K. Criswell et al. Use of acridine orange in flow cytometric assessment of micronuclei induction. Mutat. Res. 414 (1998) 63.

14. On the Protection of Animals from Cruelty. Law of Ukraine of February 21, 2006, No. 3447. Bulletin of the Verkhovna Rada of Ukraine 27 (2006) 230. (Ukr)

15. Atlas of the Chornobyl Exclusion Zone. V.M. Shestopalov (Ed.) (Kyiv: Kartografiya, 1996) 26 p. (Ukr)

16. V.A. Gaychenko, O.Yu. Krainiuk. Peculiarities of absorbed dose forming in some wild animals in Chornobyl exclusion zone. Nucl. Phys. At. Energy 16(3) (2015) 287. https://doi.org/10.15407/jnpae2015.03.287

17. Yu.A. Maklyuk et al. Values and structure of dose burdens in small mammals of the Chernobyl zone in 19 years after the accident. Nucl. Phys. At. Energy 3(21) (2007) 81. (Rus) https://jnpae.kinr.kyiv.ua/21(3)/Articles_PDF/jnpae-2007-3(21)-0081-Maklyuk.pdf

18. ICRP Publication 108. Environmental protection: the concept and use of reference animals and plants. Ann. ICRP 38(4-6) (2008) 1. https://journals.sagepub.com/toc/anib/38/4-6

19. Y. Iseki et al. Hematopoietic stem cells in the mouse spleen. Blood 11(112) (2008) 2421. https://doi.org/10.1182/blood.V112.11.2421.2421

20. Î. Oberenko, V. Klimenko. Peripheral blood leukocyte indices in persons working in 30 kilometer zone of Chernobyl NPP and workers of chemical enterprise. Likarska sprava (4) (1999) 10. (Rus)

21. N.I. Ryabokon et al. Long-term development of the radionuclide exposure of murine rodent populations in Belarus after the Chernobyl accident. Radiat. Environ. Biophys. 44 (2005) 169. https://doi.org/10.1007/s00411-005-0015-2

22. E. Rodgers, R.J. Baker. Frequencies of micronuclei in bank voles from zone of high radiation at Chornobyl, Ukraine. Environmental Toxicology and Chemistry 19 (2000) 1644. https://doi.org/10.1002/etc.5620190623

23. N.M. Riabchenko, O.O. Burdo, A.I. Lypska. Cytogenetic studies of Myodes glareolus from the natural populations of the Chornobyl Exclusion Zone in the remote post-accident period. Nucl. Phys. At. Energy 23(1) (2022) 39. (Ukr) https://doi.org/10.15407/jnpae2022.01.039

24. A.I. Lypska et al. Estimation of status of small rodents' natural populations from the transformed ecosystems of the Chornobyl Exclusion Zone. Nucl. Phys. At. Energy 21 (2020) 328. (Ukr) https://doi.org/10.15407/jnpae2020.04.328