Ядерна фізика та енергетика Nuclear Physics and Atomic Energy   ISSN: 1818-331X (Print), 2074-0565 (Online)   Publisher: Institute for Nuclear Research of the National Academy of Sciences of Ukraine   Languages: Ukrainian, English   Periodicity: 4 times per year   Open access peer reviewed journal

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M. A. Zabolotnyy^1,*, L. I. Aslamova¹, G. I. Dovbeshko², O. P. Gnatyuk², V. B. Neimash², V. Yu. Povarchuk², V. E. Orel³, D. L. Kolesnyk⁴, L. M. Kirkilevska⁵, G. I. Solyanyk<sup>4

1</sup> Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
² Institute of Physics, National Academy of Sciences of Ukraine, Kyiv, Ukraine
³ National Cancer Institute, Kyiv, Ukraine
⁴ R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
⁵ Kyiv Medical University, Ukrainian Association of Folk Medicine, Kyiv, Ukraine

^*Corresponding author. E-mail address: fedcba137@ukr.net

Abstract: The effect of preliminary irradiation of an aqueous solution of sodium chloride (saline) with 1 MeV high-energy electron beams on optical and cytotoxic/cytostatic properties of the dissolved Doxorubicin cancer drug is studied. With the use of Lewis lung carcinoma cell culture, it has been shown that the said treatment results in an increased cytotoxic/cytostatic action of the Doxorubicin, being the most pronounced in the range of low concentrations of the drug. The delivered dose of ionizing radiation on the saline ranged from 4 to 80 kGy. The maximum changes in the IR absorption spectra of Doxorubicin have been observed for the solutions irradiated with 10 kGy. The possible causes of the observed effects are discussed.

Keywords: Doxorubicin, saline, high-energy electrons, delivered dose, IR absorption spectra, Lewis lung carcinoma.

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