ßäåðíà ô³çèêà òà åíåðãåòèêà
ISSN:
1818-331X (Print), 2074-0565 (Online) |
Home page | About |
Integral assessment of oxidative metabolism during long-term domestic revenue 131I in rats
Yu. P. Grynevych, A. I. Lypska, I. P. Drozd*, S. V. TeletskaAbstract: Peroxy processes in the blood of male rats of the Wistar chemiluminescence method with prolonged oral intake of 131I were investigated. It has been shown that long-term oral intake of 131I (29.3 kBq/day per animal for 14 days) causes changes in the indices of the chemiluminescent reaction (aggregate chemiluminescence, luminescence maximum and the final intensity of luminescence, time to reach maximum values). However, absolute values of these indicators are not significantly dependent on the administration of the active isotope. We discuss features of the current processes of peroxidation in the blood of laboratory rats after prolonged administration of 131I.
Keywords: iodine radioactive, lipid peroxidation, blood, chemiluminescence, Wistar rats.
References:1. J. Moskovitz, M.B. Vim, P.B. Clock. Free radicals and disease. Archiv. Biochem. Biophys. 397(2) (2002) 354. https://doi.org/10.1006/abbi.2001.2692
2. J.M. Jutteridge, Â. Hallwell Free radicals and antioxidants in the year 2000. A historical look to future. Ann. N. Y. Acad. Sci. 899 (2000) 136. https://doi.org/10.1111/j.1749-6632.2000.tb06182.x
3. Yu.V. Blagosklonnaya, E.V. Shlyakhto, A.Yu. Babenko. In: Endocrinology (Sankt-Peterburg: SpetsLit, 2004) p. 126. (Rus)
4. Ju.P. Grynevych, I.P. Drozd, A.I. Lypska et al. Peroxidase activity of the rat blood at prolonged intake of 137Cs. Yaderna Fizyka na Energetyka (Nucl. Phys. At. Energy) 14(1) (2013) 64. (Ukr) https://jnpae.kinr.kyiv.ua/14.1/Articles_PDF/jnpae-2013-14-0064-Grynevych.pdf
5. L.I. Makovetska, Ju.P. Grynevych, I.P. Drozd. Lipid peroxidation in the rat blood under the single alimentary incorporation of 90Sr + 90Y. Yaderna Fizyka ta Energetyka (Nucl. Phys. At. Energy) 3(25) (2008) 80. (Ukr) https://jnpae.kinr.kyiv.ua/25(3)/Articles_PDF/jnpae-2008-3(25)-0080-Makovetska.pdf
6. Ju.P. Grynevych, I.P. Drozd, A.I. Lypska et al. Peroxide processes in the blood of rats with prolonged oral injection of 137Cs. Annual Report of Inst. Nucl. Research NAS of Ukraine (2010) p. 126. (Ukr). https://kinr.kyiv.ua/Annual_report/report10.pdf
7. A.I. Lypska, N.K. Rodionova, N.P. Atamanyuk et al. The intensity of free radical processes and the level of DNA damage in bone marrow cells of animals under conditions of action 137Cs. Problems of Rad. Med. and Radiobiol. Scientific Papers 12 (2006) 202. (Ukr)
8. V.A. Baraboi, D.A. Sutkovoy. The Redox Homeostasis in Health and Disease. (Kyiv: Chernobylinterinform, 1997) Part ². 202 p.; Part 2. 220 p. (Rus)
9. Ya.I. Serkiz, N.A. Druzhina, A.P. Hrienko. Chemiluminescence of Blood at Radiation Exposure (Kyiv: Naukova dumka, 1989) 176 p. (Rus)
10. Yu.P. Grynevych, A.I. Lypska, I.P. Drozd et al. Lipid peroxidation in rat blood following a single administration of different active 131I. Yaderna Fizyka ta Energetyka (Nucl. Phys. At. Energy) 15(4) (2014) 353. (Ukr) https://jnpae.kinr.kyiv.ua/15.4/Articles_PDF/jnpae-2014-15-0353-Grynevych.pdf
11. Yu.P. Grynevych, A.I. Lypska, S.V. Teletska, T.V. Tsyganok. Effect of oxidative homeostasis in rats. Proc. of the Conf. “Radioecology-2014” (Kyiv, 2014) p. 244. (Ukr)
12. O.A. Sova, I.P. Drozd. Dose formation and hematologic effects with prolonged internal exposure of rats by isotope 131I. Yaderna Fizyka ta Energetyka (Nucl. Phys. At. Energy) 15(4) (2014) 359. (Ukr) https://jnpae.kinr.kyiv.ua/15.4/Articles_PDF/jnpae-2014-15-0359-Sova.pdf
13. H. Erdamar, B. Cimen, R. Saraymen et al. Increased lipid peroxidation and multinodular goiter and papillary carcinoma. Clin. Biochemistry 43(7,8) (2010) 650. https://doi.org/10.1016/j.clinbiochem.2010.02.005
14. L.I. Nadolnik, O.I. Valentyukevich. Peculiarities of the antioxidant status of the thyroid gland. Bull. Experim. Biol. Med. 144(4) (2007) 529. (Rus) https://doi.org/10.1007/s10517-007-0369-3