Ядерна фізика та енергетика Nuclear Physics and Atomic Energy   ISSN: 1818-331X (Print), 2074-0565 (Online)   Publisher: Institute for Nuclear Research of the National Academy of Sciences of Ukraine   Languages: Ukrainian, English   Periodicity: 4 times per year   Open access peer reviewed journal

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H. I. Lavrenchuk¹, Yu. B. Shevchenko², A. L. Petranovs'ka³, E. V. Pylypchuk³, I. V. Kozlovs'ka<sup>1

1</sup>SI "National Research Center for Radiation Medicine NAMS of Ukraine", Kyiv, Ukraine
²Institute for Nuclear Research, National Academy of Sciences of Ukraine, Kyiv, Ukraine
³O. O. Chuyko Institute of Surface Chemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine

Abstract: Modifying effect of magnet driven nanocomposites containing ¹⁵⁷Gd upon morpho-functional properties of cells was studied in the test system of L929 cell line culture. Modified with DTPA and DMSA magnet driven Gadolinium containing nanocomposites were found to have better cell biocompatibility: cells incubation with these NCA showed no toxicity in studied concentrations range, except the largest ones, at the same time decreasing adhesive properties of the cells. Decrease of mitotic activity along with preservation of control cell population density was observed that suggests synchronization of cell division. Oleate sodium stabilized ferrite was found to cause destructive changes in the cell culture only at the concentration of 500 μg/ml, however it decreased mitotic activity in the cell culture by 3 to 5 times in the whole concentrations range. Magnet driven nanocomposites were shown to induct apoptosis in cell culture, the extent of which depended upon agent concentration.

Keywords: neutron capture therapy, magnet driven nanocomposites, proliferation, apoptosis.

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