Ядерна фізика та енергетика Nuclear Physics and Atomic Energy   ISSN: 1818-331X (Print), 2074-0565 (Online)   Publisher: Institute for Nuclear Research of the National Academy of Sciences of Ukraine   Languages: Ukrainian, English   Periodicity: 4 times per year   Open access peer reviewed journal

Full text (ru)

T. V. Tsyganok<sup>1

1</sup>Institute for Nuclear Research, National Academy of Sciences of Ukraine, Kyiv, Ukraine

Abstract: On purpose of comparative determination of cell repair system activity of people residing without permission in the villages of ChNPP exclusion zone and of Yahotyn district, Kiev region (control group) the chromosome sensitivity of peripheral blood lymphocytes to genotoxic effect of bleomycin in vitro was studied. Chromatid break frequency per cell was a criterium for the estimation. It was found a significantly higher sensitivity to bleomycin in ChNPP exclusion zone self-settlers' group due to cell reaction of people younger than 60. For the elderly people there was revealed no significant difference.

1. Bezdrobna L., Tsyganok T., Romanova O. et al. Chromosomal Aberrations in Blood Lymphocytes of the Residents of 30-km Chornobyl NPP Exclusion Zone. Recent Research Activities about the Chernobyl NPP Accident in Belarus, Ukraine and Russia Ed. by T. Imanaka. (Res. Reactor Inst. Kyoto Univ., 2002) p. 277.

2. Iqbal Z. V., Kohn K. W., Ewig A. G., Fornace A. J. Single strand scission and repair of DNA in mammalian cells by bleomycin. Cancer Res. 36 (1976) 3834.

3. Kohn K. W., Ewig R. A. Effect of pH on the bleomycin-induced DNA single-strand scission in L1210 cells and the relation to cell survival. Cancer Res. 36 (1976) 3839.

4. Burger R. M., Peisach J., Horwitz S. B. Mechanisms of bleomycin action: In vitro studies. Life Sci. 28 (1981) 715. https://doi.org/10.1016/0024-3205(81)90153-3

5. Hsu T. C., Johnston D. A., Cherry L. M. et al. Sensitivity to genotoxic effects of bleomycin in humans: Possible relationship to environmental carcionogenesis. Int. J. Cancer 43 (1989) 403. https://doi.org/10.1002/ijc.2910430310

6. Hsu T. C., Spitz M. R., Sctantz S. P. Mutagen sensitivity: a biological marker of cancer susceptibility. Cancer Epidemiol. Biomarkers Preven. 1 (1991) 83.

7. Paterson M. C., Smith P. J. ATAXIA TELANGIECTASIA: An Inherited Human Disorder Involving Hypersensitivity to Ionizing Radiation and Related DNA-Damaging Chemicals. Ann. Rev. Genet. 13 (1979) 291. https://doi.org/10.1146/annurev.ge.13.120179.001451

8. Biological Dosimetry: Chromosomal aberration analysis for dose assessment. Technical Reports № 260 (IAEA, Vienna, 1986).

9. Урбах В. Ю. Математическая статистика для биологов и медиков (Москва: Изд-во АН СССР, 1963) 323 c.

10. Романова О. П., Бездробна Л. К., Дрозд І. П. Біоіндикація надфонового опромінення мешканців радіаційно забруднених територій за мікроядерним тестом. Український радіологічний журнал 9 (2001) 63.